Please see below items about the Ruepp Lab, The Brain Bank, Antonio Valentin, Bradley Smith, Verity McClelland, Frank Hirth and Sandrine Thuret Lab groups.
Deepak Khuperkar from the Ruepp Lab has won UK DRI Proteomics Award to explore mechanisms of cold-shock protein RBM3-mediated neuroprotection using an RNA aptamer-based Omics approach.
The Brain Bank can now offer ‘living’ tissue samples in addition to our substantial post-mortem tissue collection. Over the last few years, we have been working with our neurosurgery colleagues at KCH to facilitate the collection of ‘living’ tissue samples and have developed a successful process for collection of surgically resected tissue straight from theatres. In the last couple of months, we have also formed a collaboration with the lumbar puncture clinic team to collect CSF samples.
All processes, from consent to collection, are covered under our tissue bank ethics and we can
delegate approval for research projects using the tissue. Please feel free to get in touch to discuss how surgical tissue might aid your research.
News from the Valentin Lab
The Antonio Valentin Lab has started a new grant in collaboration with GOSH, and were recently featured on the BBC (see the attached link below from GOSH).
https://www.kch.nhs.uk/news/clinical-trial-using-new-device-to-treat-children-with-epilepsy
News from the Bradley Smith Lab
A collaboration between the Smith, Fanto and Troakes labs at Denmark Hill working with Corinne Houart at CDN have recently published in the journal Brain:
Annexin A11 mutations are associated with nuclear envelope dysfunction in vivo and in human tissue. https://pubmed.ncbi.nlm.nih.gov/38989900/
Verity McClelland’s Lab News
Verity’s group have just had an article published in Clinical Neurophysiology:
EEG-based sensorimotor neurofeedback for motor neurorehabilitation in children and adults: a scoping review.
https://doi.org/10.1016/j.clinph.2024.08.009
Daulet Sharipov, MD PhD, from the Frank Hirth Lab has been awarded King’s Outstanding Thesis Prize 2023/2024.
In his PhD thesis entitled “The role of karyopherin abnormalities in the onset and progression of synucleinopathies”, Daulet addressed the role of nuclear transport receptors called karyopherins and their alterations related to Parkinson’s disease and Lewy body dementias, all of which are characterised by the aberrant accumulation of alpha-synuclein in the brain.
Daulet completed his PhD under the supervision of Dag Aarsland, Tibor Hortobagyi and Frank Hirth. After completion, Daulet moved to Stockholm, Sweden, where he is currently a Postdoctoral Researcher in Per Svenningsson’s lab at the Karolinska Institutet. His research continues to focus on neurodegeneration, exploring new blood biomarkers and pharmaceutical targets to find a lasting treatment for Parkinson’s Disease and Lewy Body Dementia.
Thuret Lab news
A warm welcome to Gargi Mandal joining the Thuret Lab as a new NIHR Maudsley BRC-funded PhD student who will be working on a project investigating hippocampal neurogenesis as a biomarker to predict treatment response in Major Depressive Disorder.
Congratulations to Dr Andrea Du Preez et al. for exciting new findings published in Age and Ageing in an article entitled “Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing” https://doi.org/10.1093/ageing/afae042
Our research highlights an important role for diet/nutrition in modifying dementia and depression risk in individuals with a neurogenesis-centred susceptibility.
Congratulations to Dr Curie Kim et al. for leading on a new review from the Thuret Lab and collaborators exploring “The dynamic influence of nutrition on prolonged cognitive healthspan across the life course” published in Neuroscience Applied.
Cognitive function improves rapidly during childhood neurodevelopment, followed by stabilisation and maintenance during adulthood to a steady decline during ageing. We argue that this pattern aligns with the fluctuating energy and nutritional demands of the brain at each life stage, presenting opportunities for targeted nutritional interventions.https://doi.org/10.1016/j.nsa.2024.104072
