Alessio Delogu

alessio.delogu@kcl.ac.uk

Delogu_KCL

Website

Research Interests

My laboratory investigates the development and function of diverse classes of inhibitory neurons in subcortical brain structures, with emphasis on the thalamus. The thalamus plays a central role in sensory perception, attention and the sleep-wake cycle, and its dysfunction contributes to several psychiatric disorders. Our experimental approach relies mostly animal models for the combined application of functional neuroanatomy, genetic manipulations and behavioural tests to ultimately understand the role of inhibitory neurons in health and disease. Using a comparative approach, we test the principles derived from animal models, to identify unique features of human brain

Most significant discovery

My laboratory is credited with the discovery of the developmental origins of the inhibitory interneurons of the thalamus (The Thalamus, Halassa M. (Ed), Cambridge University Press, 2022).

Educational Interests

• Lecturing on sleep and circadian rhythms, learning and
memory and neuroanatomy on BSc and MSc degrees.
• Personal tutoring roles for BSc, MSc and PhD students.
• Chair of the Assessment Board for Neuroscience

Top 4 Publications

Brock, O. (…) Delogu A. A role for thalamic projection GABAergic neurons in circadian responses to light. The Journal of Neuroscience, 2022

Jager P. (…) Delogu A. Dual midbrain and forebrain origins of thalamic inhibitory interneurons. Elife, 2021

Huisman C. (…) Delogu A., Lee JW. Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators. Nat Commun. 2019

Jager P. (…) Delogu A. Tectalderived interneurons contribute to phasic and tonic inhibition in the visual thalamus. Nat Commun. 2016

Methods / Expertise

Tract tracing In utero gene delivery EEG
circadian activity
Behavioural assays