Sarah Marzi

My research aims to determine the role of epigenetic regulation in neurodegenerative diseases, including ALS, Parkinson’s and Alzheimer’s disease, using state-of-the-art epigenetic and genomic techniques in cell populations and at the single-cell level. Our lab is particularly interested in linking non-coding genetic and environmental risk factors of neurodegenerative disease to functional gene regulatory mechanisms. In this context, we study chromatin biology and enhancer-driven gene regulation to identify the molecular drivers of altered cellular states and vulnerabilities. Our research group has expertise in advanced sequencing techniques, including those sensitive to epigenetic modifications, working with human brain tissue as well as in vivo and in vitro model systems.