Claire Troakes

Research Interests

My research focuses on the pathology and molecular biology of neurodegenerative disease. Over the last few years, I have been building up my own independent research theme, investigating the pathological links between head injury and neurodegeneration. Specifically, I have been working to understand how we can use the brain’s response to injury as a mechanism to examine the neurodegenerative disease processes in Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. This is a novel approach to understanding the pathophysiology of neurodegenerative conditions by observing the initiation of cellular damage rather than purely the pathological hallmarks of end-stage disease and may reveal new therapeutic targets.

Most significant discovery

Temporal expression of clusterin after head injury, localisation in neurons initially and then to astrocytes in long-term survivors – implications for secondary damage and subsequent neurodegeneration.

Educational Interests

• MSc Neuroscience Module lead
• MSc Clinical Neuroscience Module Lead
• Neuroanatomy, neuropathology and tissue banking demonstration sessions

Top 4 Publications

Methods / Expertise

• Neuropathology
• Tissue banking
• Histology/IHC/IF