Deepak P. Srivastava

deepak.srivastava@kcl.ac.uk

NCNDgroup_KCL

Website

Research Interests

The Srivastava Lab studies the development of glutamatergateric neurons as well as the formation and function of their synaptic connections. We specifically study how genes and environmental factors implicated in neurodevelopmental and psychiatric conditions influence the development and control the formation, maintenance, and remodeling of synaptic connections on how glutamatergic neurons. We are also particularly keen to elucidate how these processes differ between females and males. We use a multidisciplinary approach utilizing molecular, biochemical, and advanced microscopy approaches. We predominantly use patient-specific induced pluripotent stem cells to study the neurobiology of neurodevelopmental and psychiatric disorders.

Most significant discovery

Cellular memory of mother’s viral infection could play a role in child’s later brain development – Read article here. Autistic people’s nerve cells differ before birth – Read article here.

Educational Interests

• Memory mechanisms in health and disease
• Distance learning
• Post-graduate training
• Advanced microscopy techniques
• Digital learning approaches

Top 4 Publications

1. Bhat A, et al. Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells. Brain Behav. & Immunity. 2022. PMID: 35716830
2. Warre-Cornish K, et al. Interferon-γ signaling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes. Science Adv. 2020. PMID: 32875100
3. Adhya D, et al. Atypical Neuro-genesis in Induced Pluripotent Stem Cells From Autistic Individuals. Bio. Psych. 2021. PMID: 32826066
4. Deans, PJM, et al, Psychosis risk candidate ZNF804A localizes to synapses…. Bio. Psych. 2017. PMID: 27837918

Methods / Expertise

• Patient derived human induced pluripotent stem cell models
• Organoid models
• Super-resolution imaging
• Advanced live-cell Imaging
• High-content imaging and transcriptomics