Emma Clayton

My group are interested in synaptopathy in frontotemporal dementia and amyotrophic lateral sclerosis. Synaptic pathology is an early event in numerous neurodegenerative conditions. However, how synapse loss leads to neuron death is not well understood. We are developing novel tools to specifically interrogate the ‘omics of the presynaptic terminal. Coupled with super resolution imaging, we aim to identify a common pathomechanism leading to synaptic dysfunction early in disease course. Through identifying these fundamental molecular mechanisms which precede synapse loss and neuron death, we aim to identify novel therapeutic targets for disease intervention.