Jacqueline Mitchell

Jacqueline.mitchell@kcl.ac.uk

MitchellLab3

Website

Research Interests

My lab is focused on using mouse models to help understand the mechanisms that underpin neurodegenerative diseases, with a specific interest in exploring how environmental factors may feed into disease onset and progression, both directly, and in combination with known genetic risks. Two key areas of interest currently are the role of cellular stress and the stress granule response in TDP-43 linked disease, and the impact of dietary manipulation/nutritional status on neurodegenerative disease processes, with a focus on neuron – microglia interactions.

Most significant discovery

Recent work in our lab has identified key differences in the distribution and interactome disease processes. of TDP-43 between the cortex and cerebellum, brain regions that are vulnerable and resistant to TDP-43 disease pathology respectively. Work is still ongoing in this area, but it may provide key new insight into disease causative mechanisms in the future.

Educational Interests

• In vivo modelling
• Cellular and molecular neuroscience
• Research methods
• Neurodegeneration

Top 4 Publications

• Solomon et al, 2022, Cell Mol Life Sci DOI: 10.1007/ s00018-022-04473-1
• L e e e t a l , 2 0 2 1 , Human Molecular G e n e t i c s D O I : 10.1093/hmg/ ddab227
• Chen et al, 2016, Brain DOI: 10.1093/ brain/aww028
• Mitchell et al, 2015, Acta Neuropath Coms D O I : 1 0 . 1 1 8 6 / s40478-015-0212-4

Methods / Expertise

• Mouse behaviour
• Rodent surgery
• Organotypic slice cultures
• IHC/WB
• PCR/qPCR