Publications
The Department of Basic & Clinical Neuroscience publishes research covering a wide area from fundamental molecular and cellular studies and preclinical animal models to clinical trials.
2025
- Biomarkers in ALS trials: from discovery to clinical utility
- Topographic Variation in Human Neurotransmitter Receptor Densities Explains Differences in Intracranial EEG Spectra
- Letter Concerning Biallelic Variants in EPG5 Gene Are Associated with Parkinson's Disease
- mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node
- Optimised machine learning for time-to-event prediction in healthcare applied to timing of gastrostomy in ALS: a multi-centre, retrospective model development and validation study
- Functional cortical mapping and structural subcortical anatomy predicts intra-operative speech arrest: a nTMS-tractography study
- Entering the era of precision medicine to treat amyotrophic lateral sclerosis
- Functional cortical mapping and structural subcortical anatomy predicts intra-operative speech arrest: a nTMS-tractography study
- Genetic and clinical landscape of Duchenne muscular dystrophy in Guatemala: insights from a national study
- Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity derived biomarkers
- Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity derived biomarkers
- Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism
- Optimised machine learning for time-to-event prediction in healthcare applied to timing of gastrostomy in ALS: a multi-centre, retrospective model development and validation study
- Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism
- Characterising the Periodontal Granulation Tissue Using scRNAseq
- Characterising the Periodontal Granulation Tissue Using scRNAseq
- Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism
- Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism
- The impact of CYP2D6 variants on amyotrophic lateral sclerosis risk and survival: a pharmacogenetic analysis
- Current Position and Future Direction of Inflammation in Neuropsychiatric Disorders: A Review
- The impact of CYP2D6 variants on amyotrophic lateral sclerosis risk and survival: a pharmacogenetic analysis
- Cortico-cortical evoked potentials: Analytical techniques and emerging paradigms for epileptogenic zone localization
- Extracting epilepsy-related information from unstructured clinic letters using large language models
- Co-occurring functional neurological disorder and autism: an exploratory study of comorbidities in a retrospective cohort study using TriNetX
- Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-In-Schizophrenia 1 (DISC1)
- Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-In-Schizophrenia 1 (DISC1)
- Effects of a four-strain probiotic on gut microbiota, inflammation, and symptoms in Parkinson’s disease: a Randomised Clinical Trial
- Effects of a four-strain probiotic on gut microbiota, inflammation, and symptoms in Parkinson’s disease: a Randomised Clinical Trial
- The Emerging Role of the DDAH Proteins in Psychiatric Disorders
- Brief transcranial focused ultrasound stimulation causes lasting modifications to the synaptic circuitry of the hippocampus
- Transdermal, Infusion, and Surgical Therapies and Effect on Sleep Dysfunction in Parkinson's Disease
- Brief transcranial focused ultrasound stimulation causes lasting modifications to the synaptic circuitry of the hippocampus
- Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age
- The Emerging Role of the DDAH Proteins in Psychiatric Disorders
- Transdermal, Infusion, and Surgical Therapies and Effect on Sleep Dysfunction in Parkinson's Disease
- Nanoneedles enable spatiotemporal lipidomics of living tissues
- Brain anatomy of the Cambrian fossil Jianfengia multisegmentalis informs euarthropod phylogeny
- Brain anatomy of the Cambrian fossil Jianfengia multisegmentalis informs euarthropod phylogeny
- Unnerving Cough in CANVAS: Cough Hypersensitivity Despite Airway Nerve Depletion
- Dopamine and Mood in Psychotic Disorders: An 18F-DOPA PET Study
- Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis
- Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis
- Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis
- Unnerving Cough in CANVAS: Cough Hypersensitivity Despite Airway Nerve Depletion
- Brain anatomy of the Cambrian fossil Jianfengia multisegmentalis informs euarthropod phylogeny
- Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT
- A Framework for Flexible Extraction of Clinical Event Contextual Properties from Electronic Health Records
- Can laboratory test-based frailty indices contribute to frailty screening in emergency departments?
- Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT
- Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age
- Treatment Selection and Prioritization for the EJS ACT-PD MAMS Trial Platform
- Leveraging Global Genetics Resources to Enhance Polygenic Prediction Across Ancestrally Diverse Populations
- Leveraging Global Genetics Resources to Enhance Polygenic Prediction Across Ancestrally Diverse Populations
- Extracting epilepsy-related information from unstructured clinic letters using large language models
- Current Position and Future Direction of Inflammation in Neuropsychiatric Disorders: A Review
- Can laboratory test-based frailty indices contribute to frailty screening in emergency departments?
- Treatment Selection and Prioritization for the EJS ACT-PD MAMS Trial Platform
- Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis
- Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis
- Brain and body energy metabolism and potential for treatment of psychiatric disorders
- Brain and body energy metabolism and potential for treatment of psychiatric disorders
- Using prodromal non-motor symptoms to predict Parkinson's disease onset and motor phenotype
- The value of mental science: we publish what matters
- The value of mental science: we publish what matters
- Type-Specific Single-Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes
- Mental health and personal resourcefulness in adversity: A mixed-methods evaluation of a wellbeing program for university students in London.
- Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders
- Mental health and personal resourcefulness in adversity: A mixed-methods evaluation of a wellbeing program for university students in London.
- Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders
- Type-Specific Single-Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes
- Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics
- Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics
- A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
- Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial
- Epigallocatechin-3-gallate binds tandem RNA recognition motifs of TDP-43 and inhibits its aggregation
- Epigallocatechin-3-gallate binds tandem RNA recognition motifs of TDP-43 and inhibits its aggregation
- Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS
- CHAS infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders
- EEG functional connectivity as a prognostic biomarker of adaptive function in autistic people
- CHAS infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders
- EEG functional connectivity as a prognostic biomarker of adaptive function in autistic people
- Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS
- Acceptance and Commitment Therapy for people living with motor neuron disease: the COMMEND feasibility study and randomised controlled trial
- Acceptance and Commitment Therapy for people living with motor neuron disease: the COMMEND feasibility study and randomised controlled trial
- A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
- Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial
- Genomic landscape of diffuse glioma revealed by whole genome sequencing
- Genomic landscape of diffuse glioma revealed by whole genome sequencing
- Investigating the performance of Oxford Nanopore long-read sequencing with respect to Illumina microarrays and short-read sequencing
- Computational analysis of learning in young and ageing brains
- Computational analysis of learning in young and ageing brains
- Randomised controlled feasibility trial of online group acceptance and commitment therapy for functional cognitive disorder
- Racial and ethnic disparities in aortic stenosis within a universal healthcare system characterized by natural language processing for targeted intervention
- Spinal cord injury in abusive and accidental head injury in children, a neuropathological investigation
- Racial and ethnic disparities in aortic stenosis within a universal healthcare system characterized by natural language processing for targeted intervention
- Spinal cord injury in abusive and accidental head injury in children, a neuropathological investigation
- Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing
- Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing
- Service use, health care costs, and productivity losses of functional cognitive disorder in a sample of attenders to outpatient cognitive, neurology, and memory clinics.
- Modelling Population Genetic Screening in Rare Neurodegenerative Diseases
- Selenium deficiency negatively affects survival and integrity of human hippocampal progenitor cells
- The early warning paradox
- Natural Language Processing to Extract Head and Neck Cancer Data From Unstructured Electronic Health Records
- Motor and sensory neurophysiology in relation to [18F]FDG PET imaging in children with dystonia
- A generalized epilepsy network derived from brain abnormalities and deep brain stimulation
- Cross-frequency Mutual Information for Cortico-muscular Coupling Detection
- Cost-utility of specialist physiotherapy for functional motor disorder(Physio4FMD):economic analysis of a pragmatic randomised control trial
- Cognition on the move: Examining the role of physical exercise and neurogenesis in counteracting cognitive aging
- MenoScale: A novel digital tool to measure menopause symptoms and subjective quality of life – validation, preliminary insights on the menopausal experience and association with diet quality
- What can we learn from 68 000 clinical frailty scale scores? Evaluating the utility of frailty assessment in emergency departments
- Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson's Disease Psychosis
- Brain Inspired Learning for Neural Networks
- Brain Inspired Learning for Neural Networks
- Natural Language Processing to Extract Head and Neck Cancer Data From Unstructured Electronic Health Records
- Interictal discharges spread along local recurrent networks between tubers and surrounding cortex
- Neuradicon: Operational representation learning of neuroimaging reports
- Structural and functional studies of the VAPB-PTPIP51 ER-mitochondria tethering proteins in neurodegenerative diseases
- Longitudinal alterations in brain networks and thalamocortical connectivity in paediatric focal epilepsy: a structural connectomics pilot study
- Outcomes of deep brain stimulation surgery in the management of dystonia in glutaric aciduria type 1
- Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study
- Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics
- Structural and functional studies of the VAPB-PTPIP51 ER-mitochondria tethering proteins in neurodegenerative diseases
- Stroke in adults with primary intracranial tumours
- Mineral Stress Drives Loss of Heterochromatin: An Early Harbinger of Vascular Inflammaging and Calcification
- Oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling and therapeutic implications
- Which factors predict outcome from specialist physiotherapy for functional motor disorder? Prognostic modelling of the Physio4FMD intervention
- A molecular mechanism mediating clozapine-enhanced sensorimotor gating
- Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD.
- Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD.
- Brain distribution study of [14C]-Riluzole following intranasal administration in mice
- A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against Mycobacterium avium complex subspecies in patients with active Crohn's disease
- Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro
- A qualitative analysis of patients’ day-to-day living with functional cognitive disorder (FCD)
- Home video review in a pediatric clinical neurophysiology led multidisciplinary team meeting
- Integrated care for mental health in epilepsy: A systematic review and meta-synthesis by the International League Against Epilepsy Integrated Mental Health Care Pathways Task Force
- RelCAT: Advancing Extraction of Clinical Inter-Entity Relationships from Unstructured Electronic Health Records
- Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank
- EEG-to-EEG: Scalp-to-Intracranial EEG Translation Using a Combination of Variational Autoencoder and Generative Adversarial Networks
- Users´ perspectives and preferences on using wearables in epilepsy: A critical review
- Co-design of a digital holistic assessment and clinical decision support framework
- The novel T107I Inherited prion disease can present as a clinical and biomarker mimic of familial Alzheimer’s disease
- Predicting longitudinal changes in adaptive function in autism using EEG functional connectivity – A developmental approach: BPNA 2025 Annual Conference, Abstracts of the Annual Meeting, 8-10 January 2025, Oxford, UK
- Zero-phase-delay connectivity increases the reliability, concordance with structure, and prognostic ability of functional connectivity metrics
- Polygenic scores for autism are associated with reduced neurite density in adults and children from the general population
- Genetic and Clinical Landscape of Duchenne Muscular Dystrophy in Guatemala: Insights from a National Study
- Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease
- Predicting longitudinal changes in adaptive function in autism using EEG functional connectivity – A developmental approach
- Antidepressant switching as a proxy phenotype for drug non-response: investigating clinical, demographic and genetic characteristics
- Towards a diagnostic test for sporadic ALS utilising deep learning and SNP microarrays
- Parent–child similarity on autism and ADHD traits and children's social functioning and psychological well-being at 3 years
- Epileptiform Activity and Seizure Risk Follow Long-Term Non-Linear Attractor Dynamics
- Synaptic inhibitory dynamics drive benzodiazepine response in pediatric status epilepticus
- nTMS in spinal cord injury: Current evidence, challenges and a future direction
- MenoScale: A novel digital tool to measure menopause symptoms and subjective quality of life – validation, preliminary insights on the menopausal experience and association with diet quality
- The novel T107I Inherited prion disease can present as a clinical and biomarker mimic of familial Alzheimer’s disease
- An update on autophagy disorders
- Cortico-cortical evoked potentials: Analytical techniques and emerging paradigms for epileptogenic zone localization
- A Framework for Flexible Extraction of Clinical Event Contextual Properties from Electronic Health Records
- Nanoneedles enable spatiotemporal lipidomics of living tissues
- How do we improve the sleep of children with epilepsy in the NHS? Report of a Policy Lab
- Motor and sensory neurophysiology in relation to [18F]FDG PET imaging in children with dystonia
- The space-time continuum in neurological disorders of the autophagosome-lysosome fusion machinery
- The space-time continuum in neurological disorders of the autophagosome-lysosome fusion machinery
- How do we improve the sleep of children with epilepsy in the NHS? Report of a Policy Lab
- nTMS in spinal cord injury: Current evidence, challenges and a future direction
- An update on autophagy disorders
- A Framework for Flexible Extraction of Clinical Event Contextual Properties from Electronic Health Records
- Effects of a Four-Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial